Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | OPCML |
| Gene Name: | OPCML |
| Protein Full Name: | Opioid-binding protein/cell adhesion molecule |
| Alias: | IgLON family member 1; IGLON1; OBCAM; OPCM; OPCM;; Opioid binding protein/cell adhesion molecule-like; Opioid-binding cell adhesion molecule |
| Mass (Da): | 38008 |
| Number AA: | 345 |
| UniProt ID: | Q14982 |
| Locus ID: | 4978 |
| COSMIC ID: | OPCML |
| Gene location on chromosome: | 11q25 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19628 |
| Percent of cancer specimens with mutations: | 0.91 |
| Gene undergoes hypermethylation: | epithelial ovarian cancer; cervical carcinoma; squamous cell lung carcinoma; hepatocellular carcinoma; gliomas; phaeochromocytoma (12%) |
| Normal role description: | Encodes for a IgLON subfamily member of the immunoglobulin protein superfamily. Binds opioids in the presence of acidic lipids. Stress-responsive and p53-regulated gene. Plays an important role in cell-cell recognition and adhesion. Suggested tumour suppressor gene that is frequently inactivated in human malignancies via LOH and hypermethylation of CpG islands. |