Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CUL7 |
| Gene Name: | CUL7 |
| Protein Full Name: | Cullin-7 |
| Alias: | CUL-7; Cullin 7; DJ20C7.5; KIAA0076 |
| Mass (Da): | 191161 |
| Number AA: | 1698 |
| UniProt ID: | Q14999 |
| Locus ID: | 9820 |
| COSMIC ID: | CUL7 |
| Gene location on chromosome: | 6p21.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19806 |
| Percent of cancer specimens with mutations: | 1.08 |
| Normal role description: | CUL7 is a cytoplasmic localized ubiquitin ligase like protein found in the SCF E3 ubiquitinating complex. The SCF complex is composed of Fbx29, ROC1, Skp1 and Cul7. This complex is thought to target and cause degradation of proteins involved in endothelial proliferation and/or differentiation. Very little is known of CUL7’s role in cancer. CUL7 is known to share homology to PARC (PARkin-like, cytoplasmic, p53-binding protein). PARC has a role in regulating the tumour suppressor protein p53 through sequestering it in the cytoplasm to inhibit its role in the nucleus. CUL7 was found to interact with p53 and may inhibit its tumour suppressor function in a similar manner |
| Commentary on involvement of protein in cancer: | Less than 3% mutations in kidney. |