Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SEPT2 |
| Gene Name: | SEPT2 |
| Protein Full Name: | Septin-2 |
| Alias: | DIFF6; KIAA0158; NEDD5; NEDD-5; Neural precursor cell expressed developmentally down-regulated protein 5; Protein NEDD5 |
| Mass (Da): | 41487 |
| Number AA: | 361 |
| UniProt ID: | Q15019 |
| Locus ID: | 4735 |
| COSMIC ID: | SEPT2 |
| Gene location on chromosome: | 2q37.3 |
| Cancer protein type: | OP (possibly) |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES (possibly) |
| Number of cancer specimens: | 19603 |
| Percent of cancer specimens with mutations: | 0.25 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | t(2;11)(q37;q23) translocation with MLL in acute myeloid leukemia |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | SEPT2 is a filament-forming GTPase required for normal organization of the actin cytoskeleton. It is required for mitotic spindle function during mitosis, and may also be required for chromosome segregation and spindle elongation during anaphase. It is also involved in ciliogenesis and cell motility and thus may promote tumour invasiveness (unknown). A t(2;11)(q37;q23) translocation with MLL is associated with acute myeloid leukemia. |