Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NCAPD2 |
| Gene Name: | NCAPD2 |
| Protein Full Name: | Condensin complex subunit 1 |
| Alias: | CAPD2; Chromosome condensation-related SMC-associated protein 1; Chromosome-associated protein D2; CND1; HCAP-D2; Non-SMC condensin I complex subunit D2; XCAP-D2 homologue |
| Mass (Da): | 157182 |
| Number AA: | 1401 |
| UniProt ID: | Q15021 |
| Locus ID: | 9918 |
| COSMIC ID: | NCAPD2 |
| Gene location on chromosome: | 12p13.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20237 |
| Percent of cancer specimens with mutations: | 0.84 |
| Normal role description: | NCAPD2 is a regulatory subunit of the condensin complex. This complex is required for DNA condensation of interphase chromatin into mitotic-like chromosomes. Mutations in this gene could inhibit proper chromatin condesation. Mutations in this gene have been found in ovarian and stomach tumors. |
| Commentary on involvement of protein in cancer: | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain. |