Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SUZ12 |
| Gene Name: | SUZ12 |
| Protein Full Name: | Polycomb protein SUZ12 |
| Alias: | CHET9; JJAZ1; KIAA0160; Polycomb protein Suz12; suppressor of zeste 12; suppressor of zeste 12 homolog (Drosophila); Suppressor of zeste 12 protein homolog |
| Mass (Da): | 83050 |
| Number AA: | 739 |
| UniProt ID: | Q15022 |
| Locus ID: | 23512 |
| COSMIC ID: | SUZ12 |
| Gene location on chromosome: | 17q11.2 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20496 |
| Percent of cancer specimens with mutations: | 0.5 |
| Deregulated in translocations: | Endometrial stromal neoplasms. Fusion partners include JJAZ1 |
| Normal role description: | Component of the PRC2 complex. |