Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ACAP1 |
| Gene Name: | ACAP1 |
| Protein Full Name: | Arf-GAP with coiled-coil, ANK repeat and PH domain |
| Alias: | ACAP1; ArfGAP with coiled-coil, ankyrin repeat and PH domains 1; CEB1; CENB1; Cnt-b1; KIAA0050; Similar to centaurin, beta 1 |
| Mass (Da): | 81536 |
| Number AA: | 740 |
| UniProt ID: | Q15027 |
| Locus ID: | 9744 |
| COSMIC ID: | ACAP1 |
| Gene location on chromosome: | 17p13.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19788 |
| Percent of cancer specimens with mutations: | 0.63 |
| Normal role description: | GTPase-activating protein for G protein, ARF. ACAP1 primary substrate is ARF6 and induces protein recycling between plasma membrane, recycling endosomes and trans-golgi network. Its GAP activity is dependent on interactions with phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid. Recycling of integrins and other adhedsion molecules from the cell surface promotes cell migration in cancer via phosphorylation of ACAP1 by AKT. |