Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | KIF14 |
| Gene Name: | KIF14 |
| Protein Full Name: | Kinesin-like protein KIF14 |
| Alias: | KIAA0042; kinesin family member 14; kinesin-like KIF14 |
| Mass (Da): | 186492 |
| Number AA: | 1648 |
| UniProt ID: | Q15058 |
| Locus ID: | 9928 |
| COSMIC ID: | KIF14 |
| Gene location on chromosome: | 1q32.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19671 |
| Percent of cancer specimens with mutations: | 1.1 |
| Normal role description: | KIF14 is a mitotic kinesin, an essential motor protein with ATPase activity in cytokinesis. It interacts with protein regulator of cytokinesis 1 (PRC1) and localizes citron kinase to the mitotic spindle. Its expression is increased in normal cells during G2/S phase transition. Expression is upregulated in breast carcinoma, retinoblastoma, NSCLC and hepatocelullar carcinoma. |