Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ZNF146 |
| Gene Name: | ZNF146 |
| Protein Full Name: | Zinc finger protein OZF |
| Alias: | Only zinc finger protein;Zinc finger protein 146 |
| Mass (Da): | 33308 |
| Number AA: | 292 |
| UniProt ID: | Q15072 |
| Locus ID: | 7705 |
| COSMIC ID: | ZNF146 |
| Gene location on chromosome: | 19q13.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19626 |
| Percent of cancer specimens with mutations: | 0.28 |
| Found in amplified chromosomal regions in human cancers: | Pancreatic Tumours |
| Normal role description: | ZNF146 is a zinc-finger domain containing protein which binds DNA. This protein may interact with UBC9/UBE2I, SUMOylation enzyme and TERF2IP telomere-binding protein. ZNF146 may function to repress gene expression. Amplification of ZNF146 has been implicated in the development of pancreatic tumours. |