Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PRKD1 |
| Gene Name: | PRKD1 |
| Protein Full Name: | Serine/threonine-protein kinase D1 |
| Alias: | EC 2.7.11.13; Kinase PKD1; KPCD1; NPKC-mu; PKCM; PKC-mu; PKD; PRKCM; PRKD1; Protein kinase C, mu type; Protein kinase D; Protein kinase D1 |
| Mass (Da): | 101704 |
| Number AA: | 912 |
| UniProt ID: | Q15139 |
| Locus ID: | 5587 |
| COSMIC ID: | PRKD1 |
| Gene location on chromosome: | 14q11 |
| Cancer protein type: | OP? |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20583 |
| Percent of cancer specimens with mutations: | 1.25 |
| Normal role description: | PRKD1 is a protein-serine/threonine kinase. PRKD1 is thought to have a role in regulating cellular trafficking, actin remodeling, gene transcription and protection from oxidative stress. PRKD1 is implicated in prostate cancer through phosphorylation of e-cadherin leading to increased malignancy and motility of tumours. |