Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PCM1 |
| Gene Name: | PCM1 |
| Protein Full Name: | Pericentriolar material 1 protein |
| Alias: | HPCM-1; PCM-1; Pericentriol material 1; Pericentriolar material 1; Pericentriolar material 1 (PTC4); Pericentriolar material-1; PTC4 |
| Mass (Da): | 228485 |
| Number AA: | 2024 |
| UniProt ID: | Q15154 |
| Locus ID: | 5108 |
| COSMIC ID: | PCM1 |
| Gene location on chromosome: | 8p22-p21.3 |
| Number of cancer specimens: | 20538 |
| Percent of cancer specimens with mutations: | 0.89 |
| Normal role description: | PCM1 plays a role in localizing several centrasomal proteins and for anchoring microtubules to the centrosome. It is also involved it the biogenesis of cilia. Mutations in this gene have been found in ovarian and stomach tumors. |
| Commentary on involvement of protein in cancer: | Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Involved in the biogenesis of cilia. |