Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | STK38 |
| Gene Name: | STK38 |
| Protein Full Name: | Serine/threonine-protein kinase 38 |
| Alias: | AA617404; DJ108K11.2; EC 2.7.11.1; NDR1 protein kinase |
| Mass (Da): | 54190 |
| Number AA: | 465 |
| UniProt ID: | Q15208 |
| Locus ID: | 11329 |
| COSMIC ID: | STK38 |
| Gene location on chromosome: | 6p21.31 |
| Cancer protein type: | OP/TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 20473 |
| Percent of cancer specimens with mutations: | 0.42 |
| Normal role description: | STK38 is a negative regulator of MAP3K1/2 signalling. Converts MAP3K2 from its phosphorylated form to its nonphosphorylated form and inhibits autophosphorylation of MAP3K2. The MAPK/ERK pathway has been implicated in oncogenesis as either a promoter or inhibitor depending on the cancer system. Thus, the role of STK38 in cancer is likely highly contextual. |