Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NONO |
| Gene Name: | NONO |
| Protein Full Name: | Non-POU domain-containing octamer-binding protein |
| Alias: | 54 kDa nuclear RNA-and DNA-binding protein; 55 kDa nuclear protein; DNA-binding p52/p100 complex, 52 kDa subunit; NMT55; Non-POU domain containing, octamer-binding; Non-Pou domain-containing octamer (ATGCAAAT) binding protein; Non-POU-domain-containing, octamer-binding; Nrb; NRB54; Nuclear RNA-binding protein, 54-kD; P54; P54nrb |
| Mass (Da): | 54232 |
| Number AA: | 471 |
| UniProt ID: | Q15233 |
| Locus ID: | 4841 |
| COSMIC ID: | NONO |
| Gene location on chromosome: | Xq12 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19929 |
| Percent of cancer specimens with mutations: | 0.49 |
| Deregulated in translocations: | Papillary renal carcinoma. Fusion partners include TFE3 |
| Normal role description: | Transcriptional regulation and RNA splicing |