Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PPP2R4 |
| Gene Name: | PPP2R4 |
| Protein Full Name: | Serine/threonine-protein phosphatase 2A activator |
| Alias: | PP2A subunit B'; PR53; PTPA |
| Mass (Da): | 40668 |
| Number AA: | 358 |
| UniProt ID: | Q15257 |
| Locus ID: | 5524 |
| COSMIC ID: | PPP2R4 |
| Gene location on chromosome: | 9q34.11 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20149 |
| Percent of cancer specimens with mutations: | 0.29 |
| Normal role description: | PPP2R4 is a protein-serine/threonine phosphatase regulatory protein. It reguates, PP2A -- one of the four main Ser/Thr phosphatases -- which is implicated in the negative reguation of cell growth and division. Mutations in this gene have been found in mouth and pancreatic cancer. |