Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | IRF4 |
| Gene Name: | IRF4 |
| Protein Full Name: | Interferon regulatory factor 4 |
| Alias: | LSIRF; Lymphocyte-specific interferon regulatory factor; Multiple myeloma oncogene 1; MUM1; NF-EM5 |
| Mass (Da): | 51772 |
| Number AA: | 451 |
| UniProt ID: | Q15306 |
| Locus ID: | 3662 |
| COSMIC ID: | IRF4 |
| Gene location on chromosome: | 6p25.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20509 |
| Percent of cancer specimens with mutations: | 0.02 |
| Deregulated in translocations: | translocation t(6;14)(p25;q32) in Multiple Myeloma; this translocation juxtaposes the IgH locus to the IRF4 gene and leads to upregulatio of IRF4. |
| Normal role description: | IRF4 is a transcription factor that regulates interferons in response to viral infection and negatively regulate Toll-like-receptors (TLRs). Deregulation of this gene, including translocation, is implicated in several cancers. |