Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | P2RY14 |
| Gene Name: | P2RY14 |
| Protein Full Name: | P2Y purinoceptor 14 |
| Alias: | GPR105; G-protein coupled receptor 105; KIAA0001; P2Y14; Purinergic receptor P2Y, G-protein coupled, 14; UDP-glucose receptor |
| Mass (Da): | 38953 |
| Number AA: | 338 |
| UniProt ID: | Q15391 |
| Locus ID: | 9934 |
| COSMIC ID: | P2RY14 |
| Gene location on chromosome: | 3q21-q25 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20098 |
| Percent of cancer specimens with mutations: | 0.42 |
| Normal role description: | P2RY14 is a G-protein coupled receptor (GPCR) that binds ligands: UDP-glucose and other UDP-sugars coupled to G-proteins. It plays a role in immune function and regulation of stem cell compartment. Mutations in this gene have been found in colon tumors. |
| Commentary on involvement of protein in cancer: | Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP. |