Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | STIL |
| Gene Name: | STIL |
| Protein Full Name: | SCL-interrupting locus protein |
| Alias: | SCL interrupting locus; SCL/TAL1 interrupting locus; sil; stil; TAL1 (SCL) interrupting locus |
| Mass (Da): | 142950 |
| Number AA: | 1287 |
| UniProt ID: | Q15468 |
| Locus ID: | 6491 |
| COSMIC ID: | STIL |
| Gene location on chromosome: | 1p32 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20238 |
| Percent of cancer specimens with mutations: | 0.74 |
| Deregulated in translocations: | T-cell ALL, fusion partner is TAL1. In this fusion, STIL is not expressed only the promoer is fused and drives TAL1 expression. |
| Normal role description: | STIL is a cytoplasm localized checkpoint protein required for embryogenesis and cell division. STIL expression is cell cycle dependent with the highest expression during G2 to M-phase. STIL regulates chromosome segregation to mediate proper distribution of chromosomes into daughter cells. STIL activity was found to be regulated by other checkpoint proteins such as Cdc2 kinase. Overexpression of STIL has been implicated in the development of various cancers. STIL expression correlates with increased cell proliferation and mitotic activity. STIL is classified as a oncogene. The STIL gene locus can also participate in a translocation event with TAL1 transcription factor. In this fusion, the STIL promoter region is translocated and fused to the TAL1 locus, driving its expression. |