Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NCOA2 |
| Gene Name: | NCOA2 |
| Protein Full Name: | Nuclear receptor coactivator 2 |
| Alias: | BHLHe75; Glucocorticoid receptor-interacting protein-1; GRIP1; KAT13C; NCoA-2; Nuclear receptor coactivator 2; TIF2; Transcriptional intermediary factor 2 |
| Mass (Da): | 159157 |
| Number AA: | 1464 |
| UniProt ID: | Q15596 |
| Locus ID: | 10499 |
| COSMIC ID: | NCOA2 |
| Gene location on chromosome: | 8q13.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20216 |
| Percent of cancer specimens with mutations: | 1.19 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | inv8(p11;q13) with KAT6A in acute myeloid leukemias |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | NCOA2 is a transcriptional coactivator for steroid and nuclear receptors and thus may have roles in cell growth, development and homeostasis. inv8(p11;q13) generates the KAT6A/NCOA2 oncogene which can bind to CREBBP and inhibit its transcription activity and is implicated in acute myeloid leukemias. |
| Commentary on involvement of protein in cancer: | involved in fusion with PAX3 |