Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TRIP11 |
| Gene Name: | TRIP11 |
| Protein Full Name: | Thyroid receptor-interacting protein 11 |
| Alias: | CEV14; Clonal evolution related gene on chromosome 14; GMAP-210; Golgi-associated microtubule-binding 210; Golgi-associated microtubule-binding protein 210; Thyroid hormone receptor interactor 11; Thyroid receptor-interacting 11; TRIP-11; Trip230; TRIPB |
| Mass (Da): | 227586 |
| Number AA: | 1979 |
| UniProt ID: | Q15643 |
| Locus ID: | 9321 |
| COSMIC ID: | TRIP11 |
| Gene location on chromosome: | 14q32 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20669 |
| Percent of cancer specimens with mutations: | 1.21 |
| Deregulated in translocations: | PDGFRB |
| Normal role description: | TRIP11 is involved in maintanence of cis-Golgi, formation of Golgi ribbons around centrosome and transcription enhancement of THRB-modulated transcription. Translocation with PDGFRB create fusion protein that can lead to oncogenesis. |