Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RHOH |
| Gene Name: | RHOH |
| Protein Full Name: | Rho-related GTP-binding protein RhoH |
| Alias: | GTP-binding protein TTF;Translocation three four protein |
| Mass (Da): | 21331 |
| Number AA: | 191 |
| UniProt ID: | Q15669 |
| Locus ID: | 399 |
| COSMIC ID: | RHOH |
| Gene location on chromosome: | 4p13 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20238 |
| Percent of cancer specimens with mutations: | 0.3 |
| Deregulated in translocations: | t(3;4)(q27;p13): BCL6 - RHOH (non-Hodgkin lymphoma cell line) t(3;4)(q27;p11): LAZ3-TTF (non-Hodgkin lymphoma); t(4;14)(p13;q32): RHOH-unknown (multiple myeloma) |
| Normal role description: | RHOH encodes for a small GTPase of the Rho subfamily that lacks intrinsic GTPase activity. It is involved in signal transduction and cytoskeletal reorganization. Acts as a negative regulator of hematopoietic progenitor cell proliferation, survival and migration. |