Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MAPRE1 |
| Gene Name: | MAPRE1 |
| Protein Full Name: | Microtubule-associated protein RP/EB family member |
| Alias: | Adenomatous polyposis coli-binding protein EB1; APC-binding protein EB1; APC-binding protein EB1 homolog; EB1; MAE1; MARE1; Microtubule-associated protein, RP/EB family, member 1 |
| Mass (Da): | 29999 |
| Number AA: | 268 |
| UniProt ID: | Q15691 |
| Locus ID: | 22919 |
| COSMIC ID: | MAPRE1 |
| Gene location on chromosome: | 20q11.1-11.23 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.19 |
| Normal role description: | MAPRE1 is a microtubule associated protein required for regulating microtubule dynamics. MAPRE1 specifically stabilizes microtubule length and growth during mitosis. MAPRE1 can also position and maintain mitotic spindles assemblies as well as position growing microtubules chains to the kinetochore. MAPRE1 may have a role in cancer development but no mutations in this gene has been observed in any cancers. Increased transcription of MAPRE1 was observed in meduloblastoma. MAPRE1 may also have a role in colon cancer in its interaction with a truncated form of Adenomatous Polyposis Coli (APC), a tumour suppressor protein. |