Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NCOA1 |
| Gene Name: | NCOA1 |
| Protein Full Name: | Nuclear receptor coactivator 1 |
| Alias: | NCoA-1; Steroid receptor coactivator 1 |
| Mass (Da): | 156757 |
| Number AA: | 1441 |
| UniProt ID: | Q15788 |
| Locus ID: | 8648 |
| COSMIC ID: | NCOA1 |
| Gene location on chromosome: | 2p23.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19806 |
| Percent of cancer specimens with mutations: | 0.96 |
| Deregulated in translocations: | Translocation t(2;2)(q35;p23) with PAX3 --> NCOA1-PAX3 in rhabdomyosarcoma (67%) (4/6) |
| Normal role description: | NCOA1 is a transcriptional co-activator for steroid- and nuclear hormone receptors, such as the estrogen-, glucocorticoid-, and thyroid hormone receptors, and the retinoid X receptor. It possess histone acetyltransferase activity towards H3 and H4 and plays an important role in creating multisubunit coactivator complexes that participate in chromatin remodelling and in the recruitment of general transcription factors. It is resposnsible for, together with NCOA2, controlling the energy balance between white and brown adipose tissues. Translocation of the gene with with PAX3 generates an oncogenic transcriptional activator implicated in rhabdomyosarcoma. |