Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Smad2 |
| Gene Name: | SMAD2 |
| Protein Full Name: | Mothers against decapentaplegic homolog 2 |
| Alias: | JV18-1; MADH2; MADR2; Mad-related protein 2; Mothers against DPP homolog 2; Smad 2; SMAD family member 2 |
| Mass (Da): | 52306 |
| Number AA: | 467 |
| UniProt ID: | Q15796 |
| Locus ID: | 4087 |
| COSMIC ID: | SMAD2 |
| Gene location on chromosome: | 18q21.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20544 |
| Percent of cancer specimens with mutations: | 0.67 |
| Normal role description: | SMAD2 is involved in signal transduction mediating transcriptional regulation, cell proliferation, differentiation and apoptosis in response to TGF-b or activin. Loss of function mutations in cancer cause dysregulation in TFG-b signalling promotes oncogenesis. |