Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CST6 |
| Gene Name: | CST6 |
| Protein Full Name: | Cystatin-M |
| Alias: | Cystatin-6;Cystatin-E |
| Mass (Da): | 16511 |
| Number AA: | 149 |
| UniProt ID: | Q15828 |
| Locus ID: | 1474 |
| COSMIC ID: | CST6 |
| Gene location on chromosome: | 11q13.1 |
| Cancer protein type: | BOTH |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 20057 |
| Percent of cancer specimens with mutations: | 0.16 |
| Normal role description: | CST6 is a cystein protease inhibitor. It prefers endosomal and lysosomal cystein proteases. Substrates include cathespin B, cathepsin K/O2, cathepsin L and more. It is downregulated in some cancers and correlated with metastatsis and upregulated in other cancers and correlated with proliferation and progression. |