Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | STK11 |
| Gene Name: | STK11 |
| Protein Full Name: | Serine/threonine-protein kinase 11 |
| Alias: | AMPKK; EC 2.7.11.1; KPM; PJS; Renal carcinoma antigen NY-REN-19; STK11 |
| Mass (Da): | 48636 |
| Number AA: | 433 |
| UniProt ID: | Q15831 |
| Locus ID: | 6794 |
| COSMIC ID: | STK11 |
| Gene location on chromosome: | Q15831 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 5178 |
| Percent of cancer specimens with mutations: | 4.94399382 |
| General distribution of mutations: | Multi-site |
| Location of most mutations: | Broad distribution of mutation sites with many point mutations, complex mutations, insertions and deletions across entire protein |
| Mutations observed as inherited: | Peutz-Jeghers Syndrome (PJS). |
| Deregulated by viral insertion: | Lung cancers, cancers in cervix |
| Normal role description: | STK11 is a protein-serine/threonine kinase. Phosphorylates and activates AMP-activated kinase (AMPK), AMPK involved in stress responses, lipid and glucose metabolism. |