Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CCDC6 |
| Gene Name: | CCDC6 |
| Protein Full Name: | Coiled-coil domain-containing protein 6 |
| Alias: | CDNA FLJ75411, highly similar to Homo sapiens coiled-coil domain containing 6, mRNA; D10S170; D170; DNA segment on chromosome 10 (unique) 170, H4 gene (PTC1); H4 protein |
| Mass (Da): | 53291 |
| Number AA: | 585 |
| UniProt ID: | Q16204 |
| Locus ID: | 8030 |
| COSMIC ID: | CCDC6 |
| Gene location on chromosome: | 10q21.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 26644 |
| Percent of cancer specimens with mutations: | 0.23 |
| Deregulated in translocations: | inv(10)(q11.2q21): H4-RET; t(5;10)(q33;q21.2): H4-PDGFRB |
| Normal role description: | The function of CCDC6 encoded protein is unknown. Fusion proteins (H4-RET and H4-PDGFRB) are involved in Papillary thyroid carcinoma and chronic myelomonocytic leukemia. |