Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SSX1 |
| Gene Name: | SSX1 |
| Protein Full Name: | Protein SSX1 |
| Alias: | Cancer/testis antigen 5.1; Cancer/testis antigen family 5, member 1; CT5.1; SSRC; Synovial sarcoma, X breakpoint 1 |
| Mass (Da): | 21930 |
| Number AA: | 188 |
| UniProt ID: | Q16384 |
| Locus ID: | 6756 |
| COSMIC ID: | SSX1 |
| Gene location on chromosome: | Xp11.23 |
| Number of cancer specimens: | 20145 |
| Percent of cancer specimens with mutations: | 0.22 |
| Commentary on involvement of protein in cancer: | Could act as a modulator of transcription. Note, a chromosomal aberration involving SSX1 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. |