Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | BATF |
| Gene Name: | BATF |
| Protein Full Name: | Basic leucine zipper transcriptional factor ATF-li |
| Alias: | B-cell-activating transcription factor;SF-HT-activated gene 2 protein |
| Mass (Da): | 14120 |
| Number AA: | 125 |
| UniProt ID: | Q16520 |
| Locus ID: | 10538 |
| COSMIC ID: | BATF |
| Gene location on chromosome: | 14q24.3 |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.15 |
| Commentary on involvement of protein in cancer: | Functions as a negative regulator of AP-1 mediated transcription by binding to Jun proteins. Jun/B-ATF heterodimers bind DNA preferentially at the 12-O-tetradecanoylphorbol-13-acetate response element (TRE) (consensus: 5'-TGA[CG]TCA-3') and weaker at the cAMP-responsive region (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), but are transcriptionally inert. Forms heterodimers with JUN, JUNB and JUND. Also interacts with IFI35. The protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events. |