Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | HLF |
| Gene Name: | HLF |
| Protein Full Name: | Hepatic leukemia factor |
| Mass (Da): | 33199 |
| Number AA: | 295 |
| UniProt ID: | Q16534 |
| Locus ID: | 3131 |
| COSMIC ID: | HLF |
| Gene location on chromosome: | 17q22 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBIT |
| Number of cancer specimens: | 19805 |
| Percent of cancer specimens with mutations: | 0.02 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | t(17;19)(q22;p13.3) with TCF3 in pre-B-cell acute lymphoblastic leukemia |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | HLF is a transcription factor that controls apoptosis in C. elegans. A t(17;19)(q22;p13.3) translocation with TCF3 disrupts its ability to bind DNA and has been associated with pre-B-cell acute lymphoblastic leukemia. |