Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | IL17A |
| Gene Name: | IL17A |
| Protein Full Name: | Interleukin-17A |
| Alias: | Cytotoxic T-lymphocyte-associated antigen 8 |
| Mass (Da): | 17504 |
| Number AA: | 155 |
| UniProt ID: | Q16552 |
| Locus ID: | 3605 |
| COSMIC ID: | IL17A |
| Gene location on chromosome: | 6p12.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.31 |
| Normal role description: | Il17A is a pro-inflamatory cytokine that is produced by T-cells. THis protein regulates NF-kappaB and mitogen-activated protein kinase. IL17A seems to play a dual role as both tumour suppressor and oncoprotein, which is likely due distinct roles of IL17A and IL17A-producing cells in different tumors. Its deregulation is implicated in a number of neoplasms, including: including ovarian, pancreatic, renal cell, prostate, gastric, and hepatocellular cancers. |