Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CaMK4 |
| Gene Name: | CAMK4 |
| Protein Full Name: | Calcium/calmodulin-dependent protein kinase type I |
| Alias: | Brain Ca++-calmodulin-dependent protein kinase type IV; Calcium/calmodulin-dependent protein kinase IV; Calcium/calmodulin-dependent protein kinase type IV catalytic chain; Calspermin; CAM kinase- GR; CAM kinase IV; CAM kinase-GR; CaMK IV; CAMK4; CaMK-GR; CaMKIV; EC 2.7.11.17; KCC4; Kinase CaMK4 |
| Mass (Da): | 51926 |
| Number AA: | 473 |
| UniProt ID: | Q16566 |
| Locus ID: | 814 |
| COSMIC ID: | CAMK4 |
| Gene location on chromosome: | 5q22.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19878 |
| Percent of cancer specimens with mutations: | 0.64 |
| Normal role description: | CAMK4 is a calcium/calmodulin-dependent protein-serine/threonine kinase. It is implicated in immune response, inflammation, memory consolidation, positive selection of T lymphocytes, cytokine production, regulation in neurons and male germ cells, survival and differentiation of osteoblasts and dendritic cells. It regulates many transcription activators such as CREB1, and JUN. It can also activate MAPK pathway through phosphorylation of ELK1 and ATF2. |