Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RBBP7 |
| Gene Name: | RBBP7 |
| Protein Full Name: | Histone-binding protein RBBP7 |
| Alias: | G1/S transition control protein-binding protein RbAp46; Histone acetyltransferase type B subunit 2; RBAP46; RBBP-7; Retinoblastoma binding protein P46 |
| Mass (Da): | 47820 |
| Number AA: | 425 |
| UniProt ID: | Q16576 |
| Locus ID: | 5931 |
| COSMIC ID: | RBBP7 |
| Gene location on chromosome: | Xp22.2 |
| Cancer protein type: | TSP/OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.42 |
| Normal role description: | RBBP7 is a nuclear localized protein shown to bind and interact with histone proteins. RBBP7 contains many WD40 repeat domains which contributes to its function as an adapter protein. RBBP7 was found to be a component of many chromatin modifying complexes including histone acetyltransferase (HAT) complex, histone deacetytransferase (HDAC) complex and nucleosome remodelling complex. RBBP7 may work to target these complexes to nucleosomes to facilitate their function in promoting or repressing transcription of genes. RBBP7 appears to have mixed function in the development of cancer. Overexpression of RBBP7 has been observed to promote the development of leukemias while inhibiting the development of breast cancer. This mixed function may be a result of its predisposition to associate with a multitude of different complexes which may result in different function within tumour types. |