Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ECM1 |
| Gene Name: | ECM1 |
| Protein Full Name: | Extracellular matrix protein 1 |
| Alias: | Secretory component p85 |
| Mass (Da): | 60674 |
| Number AA: | 540 |
| UniProt ID: | Q16610 |
| Locus ID: | 1893 |
| COSMIC ID: | ECM1 |
| Gene location on chromosome: | 1q21.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.59 |
| Normal role description: | ECM1 is a matrix protein involved in endochondral bone formation as a negative regulator of bone mineralization. It stimulates the proliferation of endothelial cells and promotes angiogenesis. It also inhibits MMP9 proteolytic activity. Mutations of the gene are implicated in lipoid proteinosis (hyalinosis cutis et mucosae/Urbach-Wiethe disease), and expression of the gene has been found to be significantly increased in many metastatic malignant epithelial tumours. It has been shown to stimulate proliferation of cultured endothelial cells and to promote angiogenesis in the chorioallantoic membrane of chicken embryos. |
| Commentary on involvement of protein in cancer: | Only 2 ovarian samples were included in Sanger COSMIC |