Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NTRK2 |
| Gene Name: | NTRK2 |
| Protein Full Name: | BDNF/NT-3 growth factors receptor |
| Alias: | EC 2.7.10.1; GP145-TrkB; GP145-TrkB,GP95-TrkB; NTRK2 |
| Mass (Da): | 91999 |
| Number AA: | 822 |
| UniProt ID: | Q16620 |
| Locus ID: | 4915 |
| COSMIC ID: | NTRK2 |
| Gene location on chromosome: | 9q21.33 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20531 |
| Percent of cancer specimens with mutations: | 0.95 |
| Normal role description: | NTRK2 is a receptor-tyrosine kinase that is activated upon binding neurotropin 3. Active NTRK2 leads to the activation of MAPK, PI3K, and mTOR pathways, which supports tumour deveoplment and metastasis. In malignant neoplasms, overexpression of NTRK2 enhances angiogenesis and invasive potential by upregulating VEGF and matrix proteases. Mutations in this gene have been linked to kidney, colon, pancreatic, lung, and skin tumors. |