Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | POU2AF1 |
| Gene Name: | POU2AF1 |
| Protein Full Name: | POU domain class 2-associating factor 1 |
| Alias: | B-cell-specific coactivator OBF-1; BOB1; BOB-1; OBF1; OBF-1; OCAB; OCA-B; OCT-binding factor 1 |
| Mass (Da): | 27436 |
| Number AA: | 256 |
| UniProt ID: | Q16633 |
| Locus ID: | 5450 |
| COSMIC ID: | POU2AF1 |
| Gene location on chromosome: | 11q23.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20237 |
| Percent of cancer specimens with mutations: | 0.33 |
| Deregulated in translocations: | In Non-Hodgkin Lymphoma (NHL): t(3;11)(q27;q23.1), this leads to two fusion transcripts: 5' BOB1- 3' BCL6 and 5' BCL6 - 3'BOB1, but no fusion protein is formed, as promoter exchange between both partner genes occurs. |
| Normal role description: | POU2AF1 is a transcription factor that has no DNA binding activity, but it does act as a coactivator that associates with OCT1 or OCT2. Translocation of this gene has been found in Non-Hodgkin Lymphoma (NHL). The role of this gene in oncogenesis in unclear. |