Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PTGIS |
| Gene Name: | PTGIS |
| Protein Full Name: | Prostacyclin synthase |
| Alias: | Prostaglandin I2 synthase |
| Mass (Da): | 57104 |
| Number AA: | 500 |
| UniProt ID: | Q16647 |
| Locus ID: | 5740 |
| COSMIC ID: | PTGIS |
| Gene location on chromosome: | 20q13.13 |
| Cancer protein type: | ?TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19626 |
| Percent of cancer specimens with mutations: | 0.6 |
| Gene undergoes hypermethylation: | Yes - in lung and colorectal cancer |
| Normal role description: | PTGIS catalyzes the isomerization of prostaglandin H2 to prostacyclin. Evidence of hypermethylation in lung and colorectal cancer implies function as TSP. Exact mechanism of oncogenesis unclear. |