Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NRF1 |
| Gene Name: | NRF1 |
| Protein Full Name: | Nuclear respiratory factor 1 |
| Alias: | Alpha palindromic-binding protein |
| Mass (Da): | 53541 |
| Number AA: | 503 |
| UniProt ID: | Q16656 |
| Locus ID: | 4899 |
| COSMIC ID: | NRF1 |
| Gene location on chromosome: | 7q32.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.36 |
| Normal role description: | Activates genes involved in cell growth, differentiation, cellular respiration, heme synthesis etc. Can thus be speculated to be upregulated in systems requiring increased metabolic demand, including cancer. Increased NRF1 expression has been demonstrated in different cancer systems. Interestingly, NRF1 has also shown to induce transcription of known TSP. |