Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | FSCN1 |
| Gene Name: | FSCN1 |
| Protein Full Name: | FSCN1 protein |
| Alias: | Fascin |
| Mass (Da): | 55118 |
| Number AA: | 500 |
| UniProt ID: | Q16658 |
| Locus ID: | 6624 |
| COSMIC ID: | FSCN1 |
| Gene location on chromosome: | 7p22.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.33 |
| Normal role description: | FSCN1 encodes for a actin-binding protein, which is important in cell migration and cytoskeletal rearrangement, eg. in membrane ruffling and formation of membrane protrusions. Increased expression was observed in several human cancers and is associated with metastasis, invasion and cell proliferation. |
| Commentary on involvement of protein in cancer: | No known mutation listet on the Atlas of Oncology. |