Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MAPK6 |
| Gene Name: | MAPK6 |
| Protein Full Name: | Mitogen-activated protein kinase 6 |
| Alias: | EC 2.7.11.24; MAPK6; Mitogen-activated protein kinase 6; MK06; P55-MAPK; P97-MAPK; PRKM4; PRKM6 |
| Mass (Da): | 82681 |
| Number AA: | 721 |
| UniProt ID: | Q16659 |
| Locus ID: | 5597 |
| COSMIC ID: | MAPK6 |
| Gene location on chromosome: | 15q21.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20473 |
| Percent of cancer specimens with mutations: | 0.42 |
| Normal role description: | MAPK6 is a protein-serine/threonine kinase. Overexpression in fibroblasts inhibits S-phase entry. May act as a negative regulator of cell proliferation. Phosphoryltaes MAP2. Downregulated in different tumour types. However regulation and function of MAPK6 remains to be fully elucidated. |