Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CDKN3 |
| Gene Name: | CDKN3 |
| Protein Full Name: | Cyclin-dependent kinase inhibitor 3 |
| Alias: | CDK2-associated dual-specificity phosphatase;Cyclin-dependent kinase interactor 1;Cyclin-dependent kinase-interacting protein 2;Kinase-associated phosphatase |
| Mass (Da): | 23805 |
| Number AA: | 212 |
| UniProt ID: | Q16667 |
| Locus ID: | 1033 |
| COSMIC ID: | CDKN3 |
| Gene location on chromosome: | 14q22 |
| Cancer protein type: | NA |
| Effect of cancer mutation on protein: | NA |
| Effect of active protein on cancer: | NA |
| Number of cancer specimens: | 19990 |
| Percent of cancer specimens with mutations: | 0.01 |
| Normal role description: | NA |
| Commentary on involvement of protein in cancer: | This gene was reported to be deleted, mutated, or overexpressed in 'several kinds' of cancers (NCIB Gene). It's upregulated in breast & prostate cancer cells and "defected" in liver cancer (UniProt), but no additional information re: which type of defect/mutation was given... |