Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PTPN21 |
| Gene Name: | PTPN21 |
| Protein Full Name: | Tyrosine-protein phosphatase non-receptor type 21 |
| Alias: | EC 3.1.3.48; Protein tyrosine phosphatase, non-receptor type 21; Protein-tyrosine phosphatase D1; PTN21; PTPD1; PTPRL10; Tyrosine-protein phosphatase non-receptor type 21 |
| Mass (Da): | 133281 |
| Number AA: | 1174 |
| UniProt ID: | Q16825 |
| Locus ID: | 11099 |
| COSMIC ID: | PTPN21 |
| Gene location on chromosome: | 14q31.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19779 |
| Percent of cancer specimens with mutations: | 0.99 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | PTPN21 is a protein tyrosine phosphatase that can bind to and activate Src. This activated complex can upregulate EGFR phosphorylation and increase ERK1/2 signalling. It can also interact with BMX/ETK kinase and activate STAT3. Overexpression has been noted in sporadic colorectal cancer. |