Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | GEN1 |
| Gene Name: | GEN1 |
| Protein Full Name: | Flap endonuclease GEN homolog 1 |
| Alias: | FLJ40869; Gen; Gen 1, endonuclease; gen1, endonuclease; LOC348654 |
| Mass (Da): | 102884 |
| Number AA: | 908 |
| UniProt ID: | Q17RS7 |
| Locus ID: | 348654 |
| COSMIC ID: | GEN1 |
| Gene location on chromosome: | 2p24.2 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19535 |
| Percent of cancer specimens with mutations: | 0.57 |
| Normal role description: | GEN1 is a endonuclease responsible for creating symmetrical nicks in DNA across junction point to produce nicked duplex that can be ligated. This is a resolution to holliday junctions which are formed during homologous recombination. Functional loss may impair cell's ability to repair DNA and promote genomic instability. |