Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ABCB5 |
| Gene Name: | ABCB5 |
| Protein Full Name: | ATP-binding cassette sub-family B member 5 |
| Alias: | ABCB5 P-gp;P-glycoprotein ABCB5 |
| Mass (Da): | 89831 |
| Number AA: | 812 |
| UniProt ID: | Q2M3G0 |
| Locus ID: | 340273 |
| COSMIC ID: | ABCB5 |
| Gene location on chromosome: | 7p15.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19689 |
| Percent of cancer specimens with mutations: | 1.37 |
| Normal role description: | ABCB5 is a plasma membrane transporter able to mediate efflux from cells of the therapeutic drug doxorubicin. It confers resistance to doxorubicin of a subset of malignant melanomas. Primary and metastatic malignant melanomas expressed significantly more ABCB5 protein than benign melanocytic nevi, thick primary melanomas more than thin primary melanomas, and melanomas metastatic to lymph nodes more than primary lesions. Therefore, overproduction of this protein may generally facilitate oncogenesis by exporting anti-cancer drugs from tumour cells. ABC transporters like ABCB5 participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules. |