Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | C10orf137 |
| Gene Name: | EDRF1 |
| Protein Full Name: | Erythroid differentiation-related factor 1 |
| Alias: | chromosome 10 open reading frame 137; DKFZp586F1019; EDRF1; FLJ21617 |
| Mass (Da): | 138530 |
| Number AA: | 1238 |
| UniProt ID: | Q3B7T1 |
| Locus ID: | 26098 |
| COSMIC ID: | EDRF1 |
| Gene location on chromosome: | 10q26.13-q26.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20210 |
| Percent of cancer specimens with mutations: | 0.92 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | The C10orf137 encodes a transcription factor involved in the activation of the globin gene in erythrocyte differentiation. Certain missense mutations have been associated with colorectal cancer, such as N45S and L95F. |
| Commentary on involvement of protein in cancer: | no entry in AGO |