Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TBRG1 |
| Gene Name: | TBRG1 |
| Protein Full Name: | TBRG1 protein |
| Mass (Da): | 13836 |
| Number AA: | 123 |
| UniProt ID: | Q3YBR2 |
| Locus ID: | 84897 |
| COSMIC ID: | TBRG1 |
| Gene location on chromosome: | 11q24.2 |
| Number of cancer specimens: | 19603 |
| Percent of cancer specimens with mutations: | 0.1 |
| Commentary on involvement of protein in cancer: | Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability. |