Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | USP38 |
| Gene Name: | USP38 |
| Protein Full Name: | Ubiquitin carboxyl-terminal hydrolase 38 |
| Alias: | Deubiquitinating enzyme 38; HP43.8KD; KIAA1891; Ubiquitin specific peptidase 38; Ubiquitin specific protease 38; Ubiquitin thiolesterase 38; Ubiquitin-specific-processing protease 38; UBP38 |
| Mass (Da): | 116546 |
| Number AA: | 1042 |
| UniProt ID: | Q3ZCV1 |
| Locus ID: | 84640 |
| COSMIC ID: | USP38 |
| Gene location on chromosome: | 4q31.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20150 |
| Percent of cancer specimens with mutations: | 0.64 |
| Normal role description: | USP38 is a regulatory protein with deubiquitinating specific protease activity. This protein is relatively uncharacterized and may have broad specificity to ester, thioester, amide, peptide and isopeptide bonds formed with ubiquitin. Mutations of this protein have been identified in various cancers but their functional effects have not been well characterized. |
| Commentary on involvement of protein in cancer: | No entry in Atlasgeneticsoncology.org |