Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | AMOT |
| Gene Name: | AMOT |
| Protein Full Name: | Angiomotin |
| Alias: | KIAA1071 |
| Mass (Da): | 118085 |
| Number AA: | 1084 |
| UniProt ID: | Q4VCS5 |
| Locus ID: | 154796 |
| COSMIC ID: | AMOT |
| Gene location on chromosome: | Xq23 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19626 |
| Percent of cancer specimens with mutations: | 0.71 |
| Normal role description: | Angiomotin expression in endothelial cells leads to increased cell migration, tube formation and cell-cell juction assembly, suggesting that AMOT stimulates cell motility. It also maintain tight junctions by regulating the uptake of polarity proteins at those sites. |
| Commentary on involvement of protein in cancer: | Only 1 unique ovary sample was included in the Sanger COSMIC database. Several polymorphisms have been found but none of them has shown any association with a disease. Endothelial cells expressing mutated angiomotins have been reported to fail to migrate and have decreased or inhibited angiogenesis. Mutations with deletion of 3 amino acids from the PDZ-binding motif results in inhibition of chemotaxis. |