Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ARHGAP29 |
| Gene Name: | ARHGAP29 |
| Protein Full Name: | Rho GTPase-activating protein 29 |
| Alias: | PARG1; PTPL1-associated RhoGAP protein 1; RHG29; Rho GTPase activating protein 29; Rho-type GTPase-activating protein 29 |
| Mass (Da): | 142064 |
| Number AA: | 1261 |
| UniProt ID: | Q52LW3 |
| Locus ID: | 9411 |
| COSMIC ID: | ARHGAP29 |
| Gene location on chromosome: | 1p22.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19782 |
| Percent of cancer specimens with mutations: | 1.12 |
| Gene undergoes hypermethylation: | Methylated in Mantle Cell Lymphoma in combination with frequent loss of the 1p22.1 region |
| Normal role description: | ARHGAP29 acts as a GAP for Rho-family GTPases, with highest affinity for RhoA. It was shown to regulate Rho via interaction with RAP2A. |