Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PDCD4 |
| Gene Name: | PDCD4 |
| Protein Full Name: | Programmed cell death protein 4 |
| Alias: | Nuclear antigen H371-like protein; Nuclear antigen H731-like; Protein 197,15a |
| Mass (Da): | 51721 |
| Number AA: | 469 |
| UniProt ID: | Q53EL6 |
| Locus ID: | 27250 |
| COSMIC ID: | PDCD4 |
| Gene location on chromosome: | 10q24 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBIT |
| Number of cancer specimens: | 19781 |
| Percent of cancer specimens with mutations: | 0.34 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | PDCD4 is a translation regulator protein that can inhibit EIF4A1-EIF4G interaction and prevent translation initiation. It can also downregulate MAP4K1 activity and inhibit cell invasion activity. It may also have a role in promoting apoptosis. Its expression has been noted to decrease in various tumors such as lung, colon, prostate, and breast cancers. A G120R mutation has been associated with a breast cancer sample. |