Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | AGPAT9 |
| Gene Name: | AGPAT9 |
| Protein Full Name: | Glycerol-3-phosphate acyltransferase 3 |
| Alias: | EC 2.3.1.51; HGPAT3; Lpaat-theta; Lung cancer metastasis-associated protein 1; Lysophosphatidic acid acyltransferase theta; MAG1; MAG-1; PLCH |
| Mass (Da): | 48705 |
| Number AA: | 434 |
| UniProt ID: | Q53EU6 |
| Locus ID: | 84803 |
| COSMIC ID: | AGPAT9 |
| Gene location on chromosome: | 4q21.23 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.39 |
| Normal role description: | AGPAT9 converts gylcerol-3-phosphate to lysophosphatidic acid for gylcolipid biosynthesis. This reaction is an essential initial step for de novo synthesis of triacylglycerides. This is overexpressed in many cancers leading to altered glycolipid synthesis which can alter cell signalling in favor of cancer progression. |