Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PARP10 |
| Gene Name: | PARP10 |
| Protein Full Name: | Poly [ADP-ribose] polymerase 10 |
| Alias: | PARP-10 |
| Mass (Da): | 109980 |
| Number AA: | 1025 |
| UniProt ID: | Q53GL7 |
| Locus ID: | 609564 |
| COSMIC ID: | PARP10 |
| Gene location on chromosome: | 8q24.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20179 |
| Percent of cancer specimens with mutations: | 0.61 |
| Normal role description: | May play a role in cell proliferation. May be required for the maintenance of cell cycle progression. The PARP domain possessed auto-PARP activity and modified all 4 core histones tested, with preference for histone H2A, but it did not modify MYC, MAX, histone H1, or YY1. Role in oncogenesis unclear. |